Reaction Details Report a problem with these data
Target
Neurotensin receptor type 2
Ligand
BDBM50342262
Substrate
n/a
Meas. Tech.
ChEMBL_743647 (CHEMBL1768190)
Ki
100±n/a nM
Citation
 Einsiedel, J; Held, C; Hervet, M; Plomer, M; Tschammer, N; Hübner, H; Gmeiner, P Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics. J Med Chem 54:2915-23 (2011) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 2
Synonyms:
Levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2 | NTR2 receptor | NTR2_HUMAN | NTSR2 | Neurotensin receptor | Neurotensin receptor 2 | Neurotensin receptor type 2
Type:
PROTEIN
Mol. Mass.:
45404.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1281495
Residue:
410
Sequence:
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
  
Inhibitor
Name:
BDBM50342262
Synonyms:
(S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(2-(pyridin-2-yl)ethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid | CHEMBL1766943
Type:
Small organic molecule
Emp. Form.:
C38H65N13O7
Mol. Mass.:
816.0056
SMILES:
[#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-c1ccccn1)-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](-[#8])=O |r|
Structure:
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