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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50342694
Substrate
n/a
Meas. Tech.
ChEMBL_745193 (CHEMBL1772424)
EC50
30±n/a nM
Citation
 Szewczyk, JW; Acton, J; Adams, AD; Chicchi, G; Freeman, S; Howard, AD; Huang, Y; Li, C; Meinke, PT; Mosely, R; Murphy, E; Samuel, R; Santini, C; Yang, M; Zhang, Y; Zhao, K; Wood, HB Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett 21:2665-9 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50342694
Synonyms:
2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiperidin-1-yl)pyrimidine-4-carbonitrile | CHEMBL1771095
Type:
Small organic molecule
Emp. Form.:
C21H27N7
Mol. Mass.:
377.486
SMILES:
Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Structure:
Search PDB for entries with ligand similarity: