Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50343153
Substrate
n/a
Meas. Tech.
ChEMBL_745287 (CHEMBL1775319)
EC50
2.1±n/a nM
Citation
Jones, LH; Baldock, H; Bunnage, ME; Burrows, J; Clarke, N; Coghlan, M; Entwistle, D; Fairman, D; Feeder, N; Fulton, C; Hilton, L; James, K; Jones, RM; Kenyon, AS; Marshall, S; Newman, SD; Osborne, R; Patel, S; Selby, MD; Stuart, EF; Trevethick, MA; Wright, KN; Price, DA Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. Bioorg Med Chem Lett 21:2759-63 (2011) [PubMed] Article
More Info.:
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
Inhibitor
Name:
BDBM50343153
Synonyms:
CHEMBL1773197 | N-(3-(3-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)propyl)-2-(3-(2-((R)-2-hydroxy-2-(4-hydroxy-3-(methylsulfonamido)phenyl)ethylamino)-2-methylpropyl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C45H62N4O6S
Mol. Mass.:
787.062
SMILES:
CC(C)N(CC[C@H](c1ccccc1)c1cc(CCCNC(=O)Cc2cccc(CC(C)(C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)ccc1O)C(C)C |r|