Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM18133
Substrate
n/a
Meas. Tech.
ChEMBL_745625 (CHEMBL1775995)
IC50
2238721±n/a nM
Citation
 Hack, S; Wörlein, B; Höfner, G; Pabel, J; Wanner, KT Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Eur J Med Chem 46:1483-98 (2011) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13
Type:
PROTEIN
Mol. Mass.:
68283.40
Organism:
Mus musculus
Description:
ChEMBL_1460089
Residue:
602
Sequence:
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
  
Inhibitor
Name:
BDBM18133
Synonyms:
2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Glycine
Type:
Amino Acid
Emp. Form.:
C2H5NO2
Mol. Mass.:
75.0666
SMILES:
NCC(O)=O
Structure:
Search PDB for entries with ligand similarity: