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Target
HTH-type transcriptional regulator EthR
Ligand
BDBM50343351
Substrate
n/a
Meas. Tech.
ChEMBL_745892 (CHEMBL1776262)
IC50
2000±n/a nM
Citation
 Flipo, M; Desroses, M; Lecat-Guillet, N; Dirié, B; Carette, X; Leroux, F; Piveteau, C; Demirkaya, F; Lens, Z; Rucktooa, P; Villeret, V; Christophe, T; Jeon, HK; Locht, C; Brodin, P; Déprez, B; Baulard, AR; Willand, N Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors. J Med Chem 54:2994-3010 (2011) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator EthR
Synonyms:
ETHR_MYCTU | HTH-type transcriptional regulator EthR | Transcriptional repressor EthR (EthR) | etaR | ethR
Type:
Protein
Mol. Mass.:
23751.94
Organism:
Mycobacterium tuberculosis
Description:
P9WMC1
Residue:
216
Sequence:
MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR
  
Inhibitor
Name:
BDBM50343351
Synonyms:
4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-pyrrolidin-1-yl]-butan-1-one | CHEMBL1773975
Type:
Small organic molecule
Emp. Form.:
C14H14F3N3O2S
Mol. Mass.:
345.34
SMILES:
FC(F)(F)CCC(=O)N1CC[C@H](C1)c1nc(no1)-c1cccs1 |r|
Structure:
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