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Target
Uracil-DNA glycosylase
Ligand
BDBM50343400
Substrate
n/a
Meas. Tech.
ChEMBL_747132 (CHEMBL1777498)
IC50
137600±n/a nM
Citation
 Nuth, M; Huang, L; Saw, YL; Schormann, N; Chattopadhyay, D; Ricciardi, RP Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4. J Med Chem 54:3260-7 (2011) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UDG | UNG | UNG_VACCW
Type:
PROTEIN
Mol. Mass.:
25071.48
Organism:
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))
Description:
ChEMBL_747132
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
  
Inhibitor
Name:
BDBM50343400
Synonyms:
(4-tert-butyl-6-{2-methyl-5H,6H-pyrazolo[1,5-c]quinazolin-5-yl}benzene-1,3-diol | CHEMBL1513961
Type:
Small organic molecule
Emp. Form.:
C21H23N3O2
Mol. Mass.:
349.4262
SMILES:
Cc1cc2-c3ccccc3NC(c3cc(c(O)cc3O)C(C)(C)C)n2n1
Structure:
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