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Target
Uracil-DNA glycosylase
Ligand
BDBM50343406
Substrate
n/a
Meas. Tech.
ChEMBL_747132 (CHEMBL1777498)
IC50
>200000±n/a nM
Citation
 Nuth, M; Huang, L; Saw, YL; Schormann, N; Chattopadhyay, D; Ricciardi, RP Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4. J Med Chem 54:3260-7 (2011) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UDG | UNG | UNG_VACCW
Type:
PROTEIN
Mol. Mass.:
25071.48
Organism:
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))
Description:
ChEMBL_747132
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
  
Inhibitor
Name:
BDBM50343406
Synonyms:
2-(2,4-dimethoxyphenylamino)-N-(3-(4-(2-fluorophenyl)piperazin-1-yl)propyl)quinoline-4-carboxamide | CHEMBL1322766
Type:
Small organic molecule
Emp. Form.:
C31H34FN5O3
Mol. Mass.:
543.6318
SMILES:
COc1ccc(Nc2cc(C(=O)NCCCN3CCN(CC3)c3ccccc3F)c3ccccc3n2)c(OC)c1
Structure:
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