Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50343606
Substrate
n/a
Meas. Tech.
ChEMBL_746047 (CHEMBL1775434)
Ki
0.11±n/a nM
Citation
 Koike, T; Hoashi, Y; Takai, T; Nakayama, M; Yukuhiro, N; Ishikawa, T; Hirai, K; Uchikawa, O 1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT2-selective agonists. J Med Chem 54:3436-44 (2011) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50343606
Synonyms:
CHEMBL1774515 | N-[2-(7-Isopropyl-1,6-dihydro-2H-indeno[5,4-b]furan-8-yl)-ethyl]cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C20H25NO2
Mol. Mass.:
311.418
SMILES:
CC(C)C1=C(CCNC(=O)C2CC2)c2c(C1)ccc1OCCc21 |c:3|
Structure:
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