Target
Sphingosine kinase 1
Ligand
BDBM50343822
Substrate
n/a
Meas. Tech.
ChEMBL_747639 (CHEMBL1777257)
Ki
450±n/a nM
Citation
 Kennedy, AJMathews, TPKharel, YField, SDMoyer, MLEast, JEHouck, JDLynch, KRMacdonald, TL Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem 54:3524-48 (2011) [PubMed]  Article 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM50343822
Synonyms:
1-carbamimidoyl-N-(10-(cyclopentylmethoxy)decyl)cyclopropanecarboxamide hydrochloride | CHEMBL1774564
Type:
Small organic molecule
Emp. Form.:
C21H39N3O2
Mol. Mass.:
365.5533
SMILES:
NC(=N)C1(CC1)C(=O)NCCCCCCCCCCOCC1CCCC1
Structure:
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