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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50343856
Substrate
n/a
Meas. Tech.
ChEMBL_747359 (CHEMBL1776704)
IC50
2900±n/a nM
Citation
 Zhu, L; Jin, J; Liu, C; Zhang, C; Sun, Y; Guo, Y; Fu, D; Chen, X; Xu, B Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors. Bioorg Med Chem 19:2797-807 (2011) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50343856
Synonyms:
4-(2-(3-(3,4-Dichlorophenyl)ureido)-6-nitroquinazolin-4-ylamino)benzoic acid | CHEMBL1774790
Type:
Small organic molecule
Emp. Form.:
C22H14Cl2N6O5
Mol. Mass.:
513.29
SMILES:
OC(=O)c1ccc(Nc2nc(NC(=O)Nc3ccc(Cl)c(Cl)c3)nc3ccc(cc23)[N+]([O-])=O)cc1
Structure:
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