Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50344110
Substrate
n/a
Meas. Tech.
ChEMBL_748609 (CHEMBL1780462)
IC50
0.4±n/a nM
Citation
 Chen, JJ; Nguyen, T; D'Amico, DC; Qian, W; Human, J; Aya, T; Biswas, K; Fotsch, C; Han, N; Liu, Q; Nishimura, N; Peterkin, TA; Yang, K; Zhu, J; Riahi, BB; Hungate, RW; Andersen, NG; Colyer, JT; Faul, MM; Kamassah, A; Wang, J; Jona, J; Kumar, G; Johnson, E; Askew, BC 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. Bioorg Med Chem Lett 21:3384-9 (2011) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50344110
Synonyms:
2-((R)-3-oxo-1-tosylpiperazin-2-yl)-N-((R)-7-(piperidin-1-ylmethyl)chroman-4-yl)acetamide | CHEMBL1777968
Type:
Small organic molecule
Emp. Form.:
C28H36N4O5S
Mol. Mass.:
540.674
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1CCNC(=O)[C@H]1CC(=O)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc12 |r|
Structure:
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