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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50344478
Substrate
n/a
Meas. Tech.
ChEMBL_747719 (CHEMBL1780874)
IC50
4.9±n/a nM
Citation
 Newhouse, BJ; Hansen, JD; Grina, J; Welch, M; Topalov, G; Littman, N; Callejo, M; Martinson, M; Galbraith, S; Laird, ER; Brandhuber, BJ; Vigers, G; Morales, T; Woessner, R; Randolph, N; Lyssikatos, J; Olivero, A Non-oxime pyrazole based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 21:3488-92 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM50344478
Synonyms:
(3R,4R)-4-(4-(2,4-dihydroindeno[1,2-c]pyrazol-6-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)piperidin-3-ol | CHEMBL1780175
Type:
Small organic molecule
Emp. Form.:
C23H22N6O
Mol. Mass.:
398.4604
SMILES:
O[C@@H]1CNCC[C@H]1n1cc(c(n1)-c1ccncc1)-c1ccc-2c(Cc3c[nH]nc-23)c1 |r|
Structure:
Search PDB for entries with ligand similarity: