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Target
Sodium/glucose cotransporter 2
Ligand
BDBM50344681
Substrate
n/a
Meas. Tech.
ChEMBL_749012 (CHEMBL1781797)
IC50
3.5±n/a nM
Citation
 Du, X; Lizarzaburu, M; Turcotte, S; Lee, T; Greenberg, J; Shan, B; Fan, P; Ling, Y; Medina, JC; Houze, J Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors. Bioorg Med Chem Lett 21:3774-9 (2011) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
SC5A2_RAT | Sglt2 | Slc5a2
Type:
PROTEIN
Mol. Mass.:
72969.23
Organism:
Rattus norvegicus
Description:
ChEMBL_938467
Residue:
670
Sequence:
MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGGLPWPALLLGLTIVSGWHWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISRCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA
  
Inhibitor
Name:
BDBM50344681
Synonyms:
6,8-dimethyl-4-((4-propyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL1779341
Type:
Small organic molecule
Emp. Form.:
C21H23N5O2
Mol. Mass.:
377.4396
SMILES:
CCCn1c(CN2C(=O)COc3c(C)cc(C)cc23)nnc1-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: