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Target
Solute carrier family 5 member 4
Ligand
BDBM50345020
Substrate
n/a
Meas. Tech.
ChEMBL_749157 (CHEMBL1780754)
IC50
89.6±n/a nM
Citation
 Kang, SY; Kim, MJ; Lee, JS; Lee, J Glucosides with cyclic diarylpolynoid as novel C-aryl glucoside SGLT2 inhibitors. Bioorg Med Chem Lett 21:3759-63 (2011) [PubMed]  Article 
Target
Name:
Solute carrier family 5 member 4
Synonyms:
Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 3 | SAAT1 | SC5A4_HUMAN | SGLT3 | SLC5A4 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4
Type:
PROTEIN
Mol. Mass.:
72452.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_764617
Residue:
659
Sequence:
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
  
Inhibitor
Name:
BDBM50345020
Synonyms:
(2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricyclo[14.2.2.0*3,8*]icosa-1(19),3(8),4,6,12,16(20),17-heptaen-5-yl)-tetrahydro-pyran-3,4,5-triol | CHEMBL1778658
Type:
Small organic molecule
Emp. Form.:
C25H30O6
Mol. Mass.:
426.5021
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCC\C=C\COc3ccc(Cc2c1)cc3 |r,t:19|
Structure:
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