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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50345262
Substrate
n/a
Meas. Tech.
ChEMBL_752074 (CHEMBL1786238)
IC50
6100±n/a nM
Citation
Xiang, Y; Hirth, B; Asmussen, G; Biemann, HP; Bishop, KA; Good, A; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Liu, J; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg Med Chem Lett 21:3050-6 (2011) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
Inhibitor
Name:
BDBM50345262
Synonyms:
CHEMBL1782533 | trans-5-bromo-7-(4-hydroxycyclohexylamino)benzofuran-2-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C15H16BrNO4
Mol. Mass.:
354.196
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O |r,wU:1.0,wD:4.7,(15.29,-27.62,;16.63,-26.85,;16.63,-25.31,;17.96,-24.55,;19.28,-25.32,;19.3,-26.86,;17.96,-27.63,;20.62,-24.55,;20.61,-23.01,;19.28,-22.24,;19.28,-20.7,;17.95,-19.93,;20.61,-19.93,;21.94,-20.69,;23.41,-20.21,;24.32,-21.45,;23.42,-22.7,;21.95,-22.24,;25.86,-21.44,;26.64,-22.77,;26.62,-20.11,)|