Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50346030
Substrate
n/a
Meas. Tech.
ChEMBL_750244 (CHEMBL1788085)
EC50
3500±n/a nM
Citation
 Pfefferkorn, JA; Lou, J; Minich, ML; Filipski, KJ; He, M; Zhou, R; Ahmed, S; Benbow, J; Perez, AG; Tu, M; Litchfield, J; Sharma, R; Metzler, K; Bourbonais, F; Huang, C; Beebe, DA; Oates, PJ Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle. Bioorg Med Chem Lett 19:3247-52 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50346030
Synonyms:
(S)-3-cyclopentyl-N-(5-methylpyrazin-2-yl)-2-(4-(methylsulfonyl)-2-oxopyridin-1(2H)-yl)propanamide | CHEMBL1270959
Type:
Small organic molecule
Emp. Form.:
C19H24N4O4S
Mol. Mass.:
404.483
SMILES:
Cc1cnc(NC(=O)[C@H](CC2CCCC2)n2ccc(cc2=O)S(C)(=O)=O)cn1 |r|
Structure:
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