Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50346143
Substrate
n/a
Meas. Tech.
ChEMBL_750676 (CHEMBL1785658)
IC50
400±n/a nM
Citation
 Alvarez, S; Alvarez, R; Khanwalkar, H; Germain, P; Lemaire, G; Rodríguez-Barrios, F; Gronemeyer, H; de Lera, AR Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists. Bioorg Med Chem 17:4345-59 (2009) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
Nr1b1 | RARA_MOUSE | Rara
Type:
PROTEIN
Mol. Mass.:
50742.79
Organism:
Mus musculus
Description:
ChEMBL_195182
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKEAPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQSP
  
Inhibitor
Name:
BDBM50346143
Synonyms:
CHEMBL1783648 | rac-4-[(1E)-3-(7,8-Dihydro-8,8-dimethyl-5-p-tolylnaphthalen-2-yl)-3-hydroxy-prop-1-en-1-yl]-benzoic Acid
Type:
Small organic molecule
Emp. Form.:
C29H28O3
Mol. Mass.:
424.5308
SMILES:
Cc1ccc(cc1)C1=CCC(C)(C)c2cc(ccc12)C(O)\C=C\c1ccc(cc1)C(O)=O |t:8|
Structure:
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