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Target
Sodium/glucose cotransporter 2
Ligand
BDBM33493
Substrate
n/a
Meas. Tech.
ChEMBL_750036 (CHEMBL1787313)
EC50
>50000±n/a nM
Citation
 Wu, JS; Peng, YH; Wu, JM; Hsieh, CJ; Wu, SH; Coumar, MS; Song, JS; Lee, JC; Tsai, CH; Chen, CT; Liu, YW; Chao, YS; Wu, SY Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening. J Med Chem 53:8770-4 (2010) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Homo sapiens (Human)
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM33493
Synonyms:
2-(3-Benzyl-2-imino-2,3-dihydro-benzoimidazol-1-yl)-ethanol | 2-(3-benzyl-2-imino-benzimidazol-1-yl)ethanol;hydrochloride | 2-(3-benzyl-2-iminobenzimidazol-1-yl)ethanol;hydrochloride | 2-[2-azanylidene-3-(phenylmethyl)benzimidazol-1-yl]ethanol;hydrochloride | 2-[2-imino-3-(phenylmethyl)-1-benzimidazolyl]ethanol;hydrochloride | CHEMBL1623333 | MLS000071043 | SMR000009266 | cid_6603635
Type:
Small organic molecule
Emp. Form.:
C16H17N3O
Mol. Mass.:
267.3257
SMILES:
OCCn1c2ccccc2n(Cc2ccccc2)c1=N
Structure:
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