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Target
Transcription factor p65
Ligand
BDBM50346334
Substrate
n/a
Meas. Tech.
ChEMBL_749381 (CHEMBL1785171)
IC50
2900±n/a nM
Citation
 Ren, Y; Matthew, S; Lantvit, DD; Ninh, TN; Chai, H; Fuchs, JR; Soejarto, DD; de Blanco, EJ; Swanson, SM; Kinghorn, AD Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. J Nat Prod 74:1117-25 (2011) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50346334
Synonyms:
1,3,7-trihydroxy-2,4-diisoprenylxanthone | CHEMBL1782240
Type:
Small organic molecule
Emp. Form.:
C23H24O5
Mol. Mass.:
380.4337
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c2oc3ccc(-[#8])cc3c(=O)c2c1-[#8]
Structure:
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