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Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM50346918
Substrate
n/a
Meas. Tech.
ChEMBL_752885 (CHEMBL1798619)
IC50
>10000±n/a nM
Citation
 Devadas, B; Selness, SR; Xing, L; Madsen, HM; Marrufo, LD; Shieh, H; Messing, DM; Yang, JZ; Morgan, HM; Anderson, GD; Webb, EG; Zhang, J; Devraj, RV; Monahan, JB Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors. Bioorg Med Chem Lett 21:3856-60 (2011) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM50346918
Synonyms:
CHEMBL1738710
Type:
Small organic molecule
Emp. Form.:
C21H18ClF2N3O4
Mol. Mass.:
449.835
SMILES:
Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO
Structure:
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