Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50249871
Substrate
n/a
Meas. Tech.
ChEMBL_754274 (CHEMBL1798961)
Ki
333±n/a nM
Citation
 Jagrat, M; Behera, J; Yabanoglu, S; Ercan, A; Ucar, G; Sinha, BN; Sankaran, V; Basu, A; Jayaprakash, V Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies. Bioorg Med Chem Lett 21:4296-300 (2011) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50249871
Synonyms:
3-phenyl-5-p-tolyl-4,5-dihydro-1H-pyrazole-1-carbothioamide | Amino[5-(4-methylphenyl)-3-phenyl(2-pyrazolinyl)]methane-1-thione | CHEMBL489743
Type:
Small organic molecule
Emp. Form.:
C17H17N3S
Mol. Mass.:
295.402
SMILES:
Cc1ccc(cc1)C1CC(=NN1C(N)=S)c1ccccc1 |c:10|
Structure:
Search PDB for entries with ligand similarity: