Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50347394
Substrate
n/a
Meas. Tech.
ChEMBL_754944 (CHEMBL1805766)
IC50
1.2±n/a nM
Citation
 Lockman, JWMurphy, BRZigar, DFJudd, WRSlattum, PMGao, ZHOstanin, KGreen, JMcKinnon, RTerry-Lorenzo, RTFleischer, TCBoniface, JJShenderovich, MWillardsen, JA Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem 53:8734-46 (2010) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50347394
Synonyms:
CHEMBL1801566
Type:
Small organic molecule
Emp. Form.:
C28H29N5O2
Mol. Mass.:
467.5622
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#7](-[#6]-c1ccc2ncn(-[#6])c(=O)c2c1)-c1ccc(cc1)-[#6](=O)-[#7]-[#6]-c1cccnc1
Structure:
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