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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50347796
Substrate
n/a
Meas. Tech.
ChEMBL_756465 (CHEMBL1804240)
IC50
65±n/a nM
Citation
 Giraud, F; Alves, G; Debiton, E; Nauton, L; Théry, V; Durieu, E; Ferandin, Y; Lozach, O; Meijer, L; Anizon, F; Pereira, E; Moreau, P Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. J Med Chem 54:4474-89 (2011) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50347796
Synonyms:
CHEMBL1802963
Type:
Small organic molecule
Emp. Form.:
C12H9BrN4
Mol. Mass.:
289.131
SMILES:
Nc1nccc(n1)-c1c[nH]c2c(Br)cccc12
Structure:
Search PDB for entries with ligand similarity: