Target
Interferon-induced, double-stranded RNA-activated protein kinase
Ligand
BDBM53035
Substrate
n/a
Meas. Tech.
ChEMBL_756675 (CHEMBL1805140)
IC50
11000±n/a nM
Citation
 Bryk, RWu, KRaimundo, BCBoardman, PEChao, PConn, GLAnderson, ECole, JLDuffy, NPNathan, CGriffin, JH Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett 21:4108-14 (2011) [PubMed]  Article 
Target
Name:
Interferon-induced, double-stranded RNA-activated protein kinase
Synonyms:
E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase
Type:
PROTEIN
Mol. Mass.:
62104.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467743
Residue:
551
Sequence:
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSGSFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC
  
Inhibitor
Name:
BDBM53035
Synonyms:
4-[(3-methyl-5-oxo-4-pyrazolyl)hydrazo]benzenesulfonamide | 4-[2-(3-methyl-5-oxidanylidene-pyrazol-4-yl)hydrazinyl]benzenesulfonamide | 4-[2-(3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazino]benzenesulfonamide | 4-[2-(3-methyl-5-oxopyrazol-4-yl)hydrazinyl]benzenesulfonamide | 4-[N'-(3-keto-5-methyl-pyrazol-4-yl)hydrazino]benzenesulfonamide | CHEMBL1802490 | MLS001180102 | SMR000477098 | cid_5349084
Type:
Small organic molecule
Emp. Form.:
C10H11N5O3S
Mol. Mass.:
281.291
SMILES:
Cc1[nH][nH]c(=O)c1N=Nc1ccc(cc1)S(N)(=O)=O |w:8.9|
Structure:
Search PDB for entries with ligand similarity: