Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50348002
Substrate
n/a
Meas. Tech.
ChEMBL_757264 (CHEMBL1803640)
IC50
500±n/a nM
Citation
 Judd, WR; Slattum, PM; Hoang, KC; Bhoite, L; Valppu, L; Alberts, G; Brown, B; Roth, B; Ostanin, K; Huang, L; Wettstein, D; Richards, B; Willardsen, JA Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem 54:5031-47 (2011) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50348002
Synonyms:
CHEMBL1800361
Type:
Small organic molecule
Emp. Form.:
C31H34N4O3S
Mol. Mass.:
542.692
SMILES:
CSCC[C@@H](NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C)C(=O)OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: