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Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50348049
Substrate
n/a
Meas. Tech.
ChEMBL_757250 (CHEMBL1803626)
IC50
31±n/a nM
Citation
 Judd, WR; Slattum, PM; Hoang, KC; Bhoite, L; Valppu, L; Alberts, G; Brown, B; Roth, B; Ostanin, K; Huang, L; Wettstein, D; Richards, B; Willardsen, JA Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem 54:5031-47 (2011) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50348049
Synonyms:
CHEMBL1800496
Type:
Small organic molecule
Emp. Form.:
C22H27F2NO2
Mol. Mass.:
375.4521
SMILES:
COc1c(F)cc(NCCC2(CCOC(C)(C)C2)c2ccccc2)cc1F
Structure:
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