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Target
Acid-sensing ion channel 1
Ligand
BDBM50348098
Substrate
n/a
Meas. Tech.
ChEMBL_757562 (CHEMBL1804677)
IC50
224±n/a nM
Citation
 Kuduk, SD; Chang, RK; Di Marco, CN; Dipardo, RM; Cook, SP; Cato, MJ; Jovanovska, A; Urban, MO; Leitl, M; Spencer, RH; Kane, SA; Hartman, GD; Bilodeau, MT Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett 21:4255-8 (2011) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 1
Synonyms:
ACCN2 | ASIC1 | ASIC1_HUMAN | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59900.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1495930
Residue:
528
Sequence:
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Inhibitor
Name:
BDBM50348098
Synonyms:
CHEMBL1800430
Type:
Small organic molecule
Emp. Form.:
C20H17ClN2S
Mol. Mass.:
352.88
SMILES:
NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Structure:
Search PDB for entries with ligand similarity: