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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50349537
Substrate
n/a
Meas. Tech.
ChEMBL_759879 (CHEMBL1810025)
IC50
2100±n/a nM
Citation
 Li, ZL; Li, QS; Zhang, HJ; Hu, Y; Zhu, DD; Zhu, HL Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors. Bioorg Med Chem 19:4413-20 (2011) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50349537
Synonyms:
CHEMBL1232305
Type:
Small organic molecule
Emp. Form.:
C9H14N3O6P
Mol. Mass.:
291.1977
SMILES:
Nc1ccn([C@H]2CC[C@@H](COP(O)(O)=O)O2)c(=O)n1 |r|
Structure:
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