Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50349652
Substrate
n/a
Meas. Tech.
ChEMBL_760041 (CHEMBL1810317)
IC50
410±n/a nM
Citation
 Thoma, G; Baenteli, R; Lewis, I; Jones, D; Kovarik, J; Streiff, MB; Zerwes, HG Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood. Bioorg Med Chem Lett 21:4745-9 (2011) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
CXCR3_RAT | Cxcr3
Type:
PROTEIN
Mol. Mass.:
40937.37
Organism:
Rattus norvegicus
Description:
ChEMBL_760041
Residue:
367
Sequence:
MYLEVSERQVLDASDIAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPVLYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAAQWVFGSGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPWVRVALTCIVVWGLCVLFALPDFIFLSASHDQRLNATHCQYNFPQVGRTALRVLQLVAGFLMPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVVAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFKEQMWMLLMRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
  
Inhibitor
Name:
BDBM50349652
Synonyms:
CHEMBL1809011
Type:
Small organic molecule
Emp. Form.:
C27H28N4O3
Mol. Mass.:
456.5362
SMILES:
OC1CCN(CC1)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4cccc(C2=C1)c34)C(=O)Nc1ccccc1 |r,c:24|
Structure:
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