Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM7657
Substrate
n/a
Meas. Tech.
ChEMBL_759530 (CHEMBL1811056)
IC50
1±n/a nM
Citation
 Ducray, R; Simpson, I; Jung, FH; Nissink, JW; Kenny, PW; Fitzek, M; Walker, GE; Ward, LT; Hudson, K Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase. Bioorg Med Chem Lett 21:4698-701 (2011) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM7657
Synonyms:
4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)amino]benzene-1-sulfonamide | CHEMBL73303 | Imidazo[1,2-a]pyridine deriv. 1h
Type:
Small organic molecule
Emp. Form.:
C17H14N6O2S
Mol. Mass.:
366.397
SMILES:
NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccccn23)cc1
Structure:
Search PDB for entries with ligand similarity: