Reaction Details Report a problem with these data
Target
Glutamate receptor 2
Ligand
BDBM50252920
Substrate
n/a
Meas. Tech.
ChEMBL_761796 (CHEMBL1817063)
Ki
80±n/a nM
Citation
 Venskutonyte, R; Butini, S; Coccone, SS; Gemma, S; Brindisi, M; Kumar, V; Guarino, E; Maramai, S; Valenti, S; Amir, A; Valadés, EA; Frydenvang, K; Kastrup, JS; Novellino, E; Campiani, G; Pickering, DS Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. J Med Chem 54:4793-805 (2011) [PubMed]  Article 
Target
Name:
Glutamate receptor 2
Synonyms:
GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2
Type:
PROTEIN
Mol. Mass.:
98691.74
Organism:
Rattus norvegicus
Description:
ChEMBL_936441
Residue:
883
Sequence:
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
  
Inhibitor
Name:
BDBM50252920
Synonyms:
(S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione | CHEMBL492469
Type:
Small organic molecule
Emp. Form.:
C9H11N3O4S
Mol. Mass.:
257.266
SMILES:
N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: