Reaction Details Report a problem with these data
Target
Adenosine kinase
Ligand
BDBM50350207
Substrate
n/a
Meas. Tech.
ChEMBL_761462 (CHEMBL1817183)
IC50
200±n/a nM
Citation
 Bourderioux, A; Naus, P; Perlíková, P; Pohl, R; Pichová, I; Votruba, I; Dzubák, P; Konecný, P; Hajdúch, M; Stray, KM; Wang, T; Ray, AS; Feng, JY; Birkus, G; Cihlar, T; Hocek, M Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines. J Med Chem 54:5498-507 (2011) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50350207
Synonyms:
CHEMBL1814776
Type:
Small organic molecule
Emp. Form.:
C13H14N4O4
Mol. Mass.:
290.2747
SMILES:
Nc1ncnc2n(cc(C#C)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: