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Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM50350421
Substrate
n/a
Meas. Tech.
ChEMBL_762463 (CHEMBL1816733)
IC50
6±n/a nM
Citation
 Maltais, R; Fournier, MA; Poirier, D Development of 3-substituted-androsterone derivatives as potent inhibitors of 17ß-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem 19:4652-68 (2011) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM50350421
Synonyms:
CHEMBL1813731
Type:
Small organic molecule
Emp. Form.:
C33H47F3N2O4S
Mol. Mass.:
624.797
SMILES:
C[C@@H]1CN([C@@H](C)CN1C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@H]23)C1)S(=O)(=O)c1ccccc1C(F)(F)F |r|
Structure:
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