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Target
Cannabinoid receptor 1
Ligand
BDBM50350436
Substrate
n/a
Meas. Tech.
ChEMBL_762512 (CHEMBL1816969)
pH
7.4±n/a
IC50
2±n/a nM
Comments
extracted
Citation
 Sasmal, PK; Talwar, R; Swetha, J; Balasubrahmanyam, D; Venkatesham, B; Rawoof, KA; Neelima Devi, B; Jadhav, VP; Khan, SK; Mohan, P; Srinivasa Reddy, D; Nyavanandi, VK; Nanduri, S; Shiva Kumar, K; Kannan, M; Srinivas, P; Nadipalli, P; Chaudhury, H; Sebastian, VJ Structure-activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists. Bioorg Med Chem Lett 21:4913-8 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50350436
Synonyms:
CHEMBL1814316
Type:
Small organic molecule
Emp. Form.:
C24H18Cl3F3N4OS
Mol. Mass.:
573.845
SMILES:
Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NC(C)(C)c1nc(cs1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: