Target
Dihydrofolate reductase
Ligand
BDBM50351176
Substrate
n/a
Meas. Tech.
ChEMBL_764179 (CHEMBL1821390)
Ki
0.3±n/a nM
Citation
 Li, XHilgers, MCunningham, MChen, ZTrzoss, MZhang, JKohnen, LLam, TCreighton, CG C, KNelson, KKwan, BStidham, MBrown-Driver, VShaw, KJFinn, J Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg Med Chem Lett 21:5171-6 (2011) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA
Type:
Enzyme
Mol. Mass.:
18249.71
Organism:
Staphylococcus aureus
Description:
n/a
Residue:
159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
  
Inhibitor
Name:
BDBM50351176
Synonyms:
CHEMBL1818126
Type:
Small organic molecule
Emp. Form.:
C21H19N5O
Mol. Mass.:
357.4085
SMILES:
CCOc1ccc(cc1-c1ccc2c(N)nc(N)nc2c1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: