Target
Dihydrofolate reductase
Ligand
BDBM50351192
Substrate
n/a
Meas. Tech.
ChEMBL_764181 (CHEMBL1821392)
Ki
743±n/a nM
Citation
 Li, XHilgers, MCunningham, MChen, ZTrzoss, MZhang, JKohnen, LLam, TCreighton, CG C, KNelson, KKwan, BStidham, MBrown-Driver, VShaw, KJFinn, J Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg Med Chem Lett 21:5171-6 (2011) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50351192
Synonyms:
CHEMBL1818107
Type:
Small organic molecule
Emp. Form.:
C14H12N4
Mol. Mass.:
236.2719
SMILES:
Nc1nc(N)c2ccc(cc2n1)-c1ccccc1
Structure:
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