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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50351321
Substrate
n/a
Meas. Tech.
ChEMBL_764331 (CHEMBL1821542)
IC50
6.4±n/a nM
Citation
 Kamata, M; Yamashita, T; Imaeda, T; Tanaka, T; Terauchi, J; Miyamoto, M; Ora, T; Tawada, M; Endo, S; Takekawa, S; Asami, A; Suzuki, N; Nagisa, Y; Nakano, Y; Watanabe, K; Ogino, H; Kato, K; Kato, K; Ishihara, Y Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem 19:5539-52 (2011) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50351321
Synonyms:
CHEMBL1818809
Type:
Small organic molecule
Emp. Form.:
C28H28N2O
Mol. Mass.:
408.5347
SMILES:
O=C(Nc1ccc2C=C(CN3CCCC3)CCc2c1)c1ccc(cc1)-c1ccccc1 |t:7|
Structure:
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