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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50351395
Substrate
n/a
Meas. Tech.
ChEMBL_764455 (CHEMBL1821007)
IC50
49±n/a nM
Citation
 Saito, T; Obitsu, T; Kondo, T; Matsui, T; Nagao, Y; Kusumi, K; Matsumura, N; Ueno, S; Kishi, A; Katsumata, S; Kagamiishi, Y; Nakai, H; Toda, M 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem 19:5432-45 (2011) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50351395
Synonyms:
CHEMBL1819085
Type:
Small organic molecule
Emp. Form.:
C21H27ClN4O
Mol. Mass.:
386.918
SMILES:
CCC(CC)Nc1c(C)c(C)nc2c(c(C)nn12)-c1ccc(OC)cc1Cl |(13.79,4.7,;12.44,3.96,;12.41,2.42,;13.73,1.62,;15.08,2.37,;11.06,1.67,;11.03,.13,;9.68,-.61,;8.36,.18,;9.65,-2.16,;8.31,-2.9,;10.98,-2.95,;12.33,-2.19,;13.79,-2.69,;14.71,-1.45,;16.25,-1.47,;13.82,-.2,;12.35,-.66,;14.25,-4.16,;13.2,-5.29,;13.66,-6.75,;15.16,-7.09,;15.62,-8.56,;14.58,-9.7,;16.21,-5.95,;15.75,-4.49,;16.79,-3.35,)|
Structure:
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