Reaction Details Report a problem with these data
Target
Luciferin 4-monooxygenase
Ligand
BDBM50352639
Substrate
n/a
Meas. Tech.
ChEMBL_766351 (CHEMBL1826377)
IC50
800±n/a nM
Citation
 Xiao, J; Marugan, JJ; Zheng, W; Titus, S; Southall, N; Cherry, JJ; Evans, M; Androphy, EJ; Austin, CP Discovery, synthesis, and biological evaluation of novel SMN protein modulators. J Med Chem 54:6215-33 (2011) [PubMed]  Article 
Target
Name:
Luciferin 4-monooxygenase
Synonyms:
LUCI_AQULA | Luciferase
Type:
PROTEIN
Mol. Mass.:
60126.66
Organism:
Luciola lateralis
Description:
ChEMBL_786225
Residue:
548
Sequence:
MENMENDENIVYGPEPFYPIEEGSAGAQLRKYMDRYAKLGAIAFTNALTGVDYTYAEYLEKSCCLGEALKNYGLVVDGRIALCSENCEEFFIPVLAGLFIGVGVAPTNEIYTLRELVHSLGISKPTIVFSSKKGLDKVITVQKTVTAIKTIVILDSKVDYRGYQSMDNFIKKNTPQGFKGSSFKTVEVNRKEQVALIMNSSGSTGLPKGVQLTHENAVTRFSHARDPIYGNQVSPGTAILTVVPFHHGFGMFTTLGYLTCGFRIVMLTKFDEETFLKTLQDYKCSSVILVPTLFAILNRSELLDKYDLSNLVEIASGGAPLSKEIGEAVARRFNLPGVRQGYGLTETTSAIIITPEGDDKPGASGKVVPLFKAKVIDLDTKKTLGPNRRGEVCVKGPMLMKGYVDNPEATREIIDEEGWLHTGDIGYYDEEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPNIFDAGVAGVPDPIAGELPGAVVVLEKGKSMTEKEVMDYVASQVSNAKRLRGGVRFVDEVPKGLTGKIDGKAIREILKKPVAKM
  
Inhibitor
Name:
BDBM50352639
Synonyms:
CHEMBL1719232
Type:
Small organic molecule
Emp. Form.:
C18H23N3O2S
Mol. Mass.:
345.459
SMILES:
CC(C)Oc1cccc(c1)-c1cnc(s1)N1CCC(CC1)C(N)=O
Structure:
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