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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50352726
Substrate
n/a
Meas. Tech.
ChEMBL_766795 (CHEMBL1827735)
IC50
42±n/a nM
Citation
 Seo, HJ; Park, EJ; Kim, MJ; Kang, SY; Lee, SH; Kim, HJ; Lee, KN; Jung, ME; Lee, M; Kim, MS; Son, EJ; Park, WK; Kim, J; Lee, J Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter. J Med Chem 54:6305-18 (2011) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50352726
Synonyms:
CHEMBL1822912
Type:
Small organic molecule
Emp. Form.:
C26H28Cl2F3N5O
Mol. Mass.:
554.435
SMILES:
Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(Cl)c2Cl)c(C)n1-c1ccccc1C(F)(F)F |(19.14,-42.83,;19.91,-41.5,;21.45,-41.5,;21.93,-40.04,;23.26,-39.27,;23.26,-37.73,;24.6,-40.04,;25.93,-39.27,;27.27,-40.04,;28.6,-39.27,;29.93,-40.03,;31.25,-39.26,;32.58,-40.02,;32.59,-41.56,;31.26,-42.33,;29.91,-41.57,;33.92,-42.32,;33.93,-43.86,;35.26,-44.63,;36.6,-43.85,;36.59,-42.31,;37.92,-41.53,;35.25,-41.55,;35.25,-40.01,;20.68,-39.13,;20.68,-37.59,;19.44,-40.04,;18.1,-39.27,;18.11,-37.73,;16.78,-36.95,;15.44,-37.72,;15.44,-39.27,;16.78,-40.04,;16.78,-41.58,;15.45,-42.35,;18.11,-42.34,;16.77,-43.11,)|
Structure:
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