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Targetalpha-1 Nicotinic AChR
LigandBDBM50352788
Substrate/Competitorn/a
Meas. Tech.ChEMBL_767064
IC50>10000±n/a nM
Citation Simoni, DRondanin, RMarchetti, PRullo, CBaruchello, RGrisolia, GBarbato, GGiovannini, RMarchioro, CCapelli, AMVirginio, CBozzoli, ABorea, PAMerighi, SDonati, D Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a. Bioorg Med Chem Lett21:5423-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
alpha-1 Nicotinic AChR
Name:alpha-1 Nicotinic AChR
Synonyms:Acetylcholine receptor protein alpha chain | Acetylcholine receptor subunit alpha | Cholinergic, Nicotinic Alpha1Beta1DeltaGamma | Cholinergic, Nicotinic Alpha1Beta2 | Nicotinic acetylcholine receptor alpha2/beta4 | n-AChR
Type:Ion channel
Mol. Mass.:54542.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:482
Sequence:
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV
KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
QG
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  Blast E-value cutoff:
BDBM50352788
NameBDBM50352788
Synonyms:CHEMBL1823384
TypeSmall organic molecule
Emp. Form.C12H18N2O2
Mol. Mass.222.2835
SMILESCc1cc(on1)[C@@]1(O)CCC[C@@H]2CC[C@H]1N2 |r|
Structure
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n/a