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TargetCathepsin D
LigandBDBM50352886
Substrate/Competitorn/a
Meas. Tech.ChEMBL_767495
IC50 8000±n/a nM
Citation Malamas, MSErdei, JGunawan, IBarnes, KHui, YJohnson, MRobichaud, AZhou, PYan, YSolvibile, WTurner, JFan, KYChopra, RBard, JPangalos, MN New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region. Bioorg Med Chem Lett21:5164-70 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin D
Name:Cathepsin D
Synonyms:Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:Enzyme
Mol. Mass.:44551.72
Organism:Homo sapiens (Human)
Description:Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50352886
NameBDBM50352886
Synonyms:CHEMBL1824355
TypeSmall organic molecule
Emp. Form.C19H15FN4OS
Mol. Mass.366.412
SMILESCN1C(N)=NC(C1=O)(c1ccsc1)c1cccc(c1)-c1cccnc1F |c:3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a