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Target
Transforming growth factor beta-1 proprotein
Ligand
BDBM50184879
Substrate
n/a
Meas. Tech.
ChEMBL_768740 (CHEMBL1831613)
IC50
19±n/a nM
Citation
 Ciayadi, R; Potdar, M; Walton, KL; Harrison, CA; Kelso, GF; Harris, SJ; Hearn, MT 2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-ß1 and activin A signalling. Bioorg Med Chem Lett 21:5642-5 (2011) [PubMed]  Article 
Target
Name:
Transforming growth factor beta-1 proprotein
Synonyms:
LAP | Latency-associated peptide | TGF-beta-1 | TGFB | TGFB1 | TGFB1_HUMAN | Transforming growth factor beta-1
Type:
PROTEIN
Mol. Mass.:
44353.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_768740
Residue:
390
Sequence:
MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
  
Inhibitor
Name:
BDBM50184879
Synonyms:
CHEMBL424676 | dimethyl-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-2-pyridinyl}phenyl)oxy]ethyl}amine
Type:
Small organic molecule
Emp. Form.:
C23H23N5O
Mol. Mass.:
385.4616
SMILES:
CN(C)CCOc1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Structure:
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