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TargetCorticotropin releasing factor receptor 1
LigandBDBM50354012
Substrate/Competitorn/a
Meas. Tech.ChEMBL_770316
IC50 31.6±n/a nM
Citation Saito, TObitsu, TMinamoto, CSugiura, TMatsumura, NUeno, SKishi, AKatsumata, SNakai, HToda, M Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF¿?) receptor antagonists. Bioorg Med Chem19:5955-66 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin releasing factor receptor 1
Name:Corticotropin releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50354012
NameBDBM50354012
Synonyms:CHEMBL1828897
TypeSmall organic molecule
Emp. Form.C21H28ClN5O
Mol. Mass.401.933
SMILESCCCN(CCC)c1cc(nc2ccnn12)N(CC)c1ccc(OC)cc1Cl
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a