Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50354594
Substrate
n/a
Meas. Tech.
ChEMBL_771219 (CHEMBL1839301)
Ki
24.2±n/a nM
Citation
 van Loevezijn, AVenhorst, JIwema Bakker, WIde Korte, CGde Looff, WVerhoog, Svan Wees, JWvan Hoeve, Mvan de Woestijne, RPvan der Neut, MABorst, AJvan Dongen, MJde Bruin, NMKeizer, HGKruse, CG N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features. J Med Chem 54:7030-54 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50354594
Synonyms:
CHEMBL1834229
Type:
Small organic molecule
Emp. Form.:
C12H15ClN4O2S
Mol. Mass.:
314.791
SMILES:
CCC1CN(N=C1)C(=N)NS(=O)(=O)c1cccc(Cl)c1 |c:5|
Structure:
Search PDB for entries with ligand similarity: