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Target
Acyl-CoA desaturase 1
Ligand
BDBM50354676
Substrate
n/a
Meas. Tech.
ChEMBL_771237 (CHEMBL1839319)
IC50
7±n/a nM
Citation
 Ramtohul, YK; Powell, D; Leclerc, JP; Leger, S; Oballa, R; Black, C; Isabel, E; Li, CS; Crane, S; Robichaud, J; Guay, J; Guiral, S; Zhang, L; Huang, Z Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors. Bioorg Med Chem Lett 21:5692-6 (2011) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50354676
Synonyms:
CHEMBL1834262
Type:
Small organic molecule
Emp. Form.:
C17H15F3N4O2S
Mol. Mass.:
396.387
SMILES:
FC(F)(F)c1ccccc1OC1CCN(CC1)c1nc2nc[nH]c(=O)c2s1
Structure:
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