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Target
Proton-coupled folate transporter
Ligand
BDBM50354833
Substrate
n/a
Meas. Tech.
ChEMBL_771182 (CHEMBL1837099)
pH
5.5±n/a
Ki
130±n/a nM
Comments
extracted
Citation
 Wang, L; Desmoulin, SK; Cherian, C; Polin, L; White, K; Kushner, J; Fulterer, A; Chang, MH; Mitchell-Ryan, S; Stout, M; Romero, MF; Hou, Z; Matherly, LH; Gangjee, A Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits b-glycinamide ribonucleotide formyltransferase. J Med Chem 54:7150-64 (2011) [PubMed]  Article 
Target
Name:
Proton-coupled folate transporter
Synonyms:
G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1
Type:
PROTEIN
Mol. Mass.:
49782.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469597
Residue:
459
Sequence:
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
  
Inhibitor
Name:
BDBM50354833
Synonyms:
AGF94 | CHEMBL1834488
Type:
Small organic molecule
Emp. Form.:
C19H21N5O6S
Mol. Mass.:
447.465
SMILES:
Nc1nc2[nH]c(CCCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r|
Structure:
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