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Target
Cystine/glutamate transporter
Ligand
BDBM39340
Substrate
n/a
Meas. Tech.
ChEMBL_772170 (CHEMBL1838227)
IC50
>1000000±n/a nM
Citation
 Shukla, K; Thomas, AG; Ferraris, DV; Hin, N; Sattler, R; Alt, J; Rojas, C; Slusher, BS; Tsukamoto, T Inhibition of xc¿?¿ transporter-mediated cystine uptake by sulfasalazine analogs. Bioorg Med Chem Lett 21:6184-7 (2011) [PubMed]  Article 
Target
Name:
Cystine/glutamate transporter
Synonyms:
SLC7A11 | XCT_HUMAN
Type:
PROTEIN
Mol. Mass.:
55437.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_772170
Residue:
501
Sequence:
MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL
  
Inhibitor
Name:
BDBM39340
Synonyms:
4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sulfadiazine) (14) | MLS000069725 | SMR000058213 | SULFAPYRIDINE | cid_5336
Type:
Small organic molecule
Emp. Form.:
C11H11N3O2S
Mol. Mass.:
249.289
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Structure:
Search PDB for entries with ligand similarity: