Reaction Details Report a problem with these data
Target
Steryl-sulfatase
Ligand
BDBM50355360
Substrate
n/a
Meas. Tech.
ChEMBL_773115 (CHEMBL1839051)
Ki
85±n/a nM
Citation
 Phan, CM; Liu, Y; Kim, BM; Mostafa, Y; Taylor, SD Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives. Bioorg Med Chem 19:5999-6005 (2011) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase
Type:
Enzyme
Mol. Mass.:
65503.66
Organism:
Homo sapiens (Human)
Description:
P08842
Residue:
583
Sequence:
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
  
Inhibitor
Name:
BDBM50355360
Synonyms:
CHEMBL1835425
Type:
Small organic molecule
Emp. Form.:
C26H30O3
Mol. Mass.:
390.5146
SMILES:
C[C@]12CC[C@H]3[C@@H](CCc4c(C=O)c(O)ccc34)[C@@H]1CC[C@@]2(O)Cc1ccccc1 |r|
Structure:
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