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Target
Serine/threonine-protein kinase OSR1
Ligand
BDBM50132260
Substrate
n/a
Meas. Tech.
ChEMBL_774457 (CHEMBL1908674)
Kd
>10000±n/a nM
Citation
 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase OSR1
Synonyms:
KIAA1101 | OSR1 | OXSR1 | OXSR1_HUMAN | Oxidative stress-responsive 1 protein
Type:
PROTEIN
Mol. Mass.:
58020.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655500
Residue:
527
Sequence:
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
  
Inhibitor
Name:
BDBM50132260
Synonyms:
2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide | 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | CHEMBL105442 | CI-1040 | PD-18435 | PD-184352 | US8575391, 341
Type:
Small organic molecule
Emp. Form.:
C17H14ClF2IN2O2
Mol. Mass.:
478.66
SMILES:
Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F
Structure:
Search PDB for entries with ligand similarity: